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Pistons vs. Knicks Prediction Tonight: Game 5 Odds & Expert Picks

Gabe Henderson

Last Updated: April 29, 2025 5:49 PM EDT • 2 min 16 sec read.

Pistons vs. Knicks Prediction Tonight: Game 5 Odds & Expert Picks, April 29
Pictured: New York Knicks forward OG Anunoby (8) drives to the basket between Detroit Pistons forward Ausar Thompson (9) and forward Tim Hardaway Jr. (8). Photo by David Reginek via Imagn Images.

The Detroit Pistons are on the brink of elimination tonight as they face the New York Knicks in Game 5 of the NBA playoffs series. Our Pistons vs. Knicks prediction - part of our NBA picks - expects the hosts to take care of business and complete the gentleman's sweep this evening.

Tipoff from Madison Square Garden in New York is set for 7:30 p.m. ET (TNT). Our best sports betting sites list the hosts as 5.5-point betting favorites with moneyline odds of -213 and a total set at 215.5.

Read on for the Pistons vs. Knicks Game 5 betting odds and expert picks.

💰 Pistons vs. Knicks expert picks for Game 5

🔎 Our NEW NBA player prop odds tool can help you find the best NBA odds across legal sportsbooks in your area!

✅ Against the spread pick: Knicks -5.5 (-108 via ESPN BET) ⭐⭐⭐
✅ Moneyline pick: Knicks ML (-213 via ESPN BET) ⭐⭐⭐⭐
✅ Over/Under pick: Over 213.5 (-110 via Caesars) ⭐⭐⭐

🏀 Game 5 prediction & best bet

🎯 Score prediction: Knicks 115, Pistons 108

Detroit came into this series looking to lean on Cade Cunningham and its gritty style. Ultimately, though, the Pistons will regret the latter, as setting a physical tone came back to bite them at the end of Game 4. Regardless of whether you believe Tim Hardaway Jr. was fouled - he was - it was a deflating blow to Detroit's chances.

The series now shifts back to the Big Apple and Madison Square Garden, where New York is 28-15 this season.

It's difficult to predict how the Pistons will come out in Game 5 after an emotionally draining two-game losing skid at home. Detroit's back is against the wall down 3-1 in the series against a more experienced side, which is not a great place to be historically.

While the Pistons may have the best player on the floor in Cunningham, the Knicks have the best scorer (Jalen Brunson) and an elite frontcourt presence (Karl-Anthony Towns). The experience and familiarity within New York's ranks have led to fewer mistakes, ultimately proving to be the difference in a tightly contested series.

For these reasons, we'll side with the Knicks. The winner in each of the past four contests has also covered the spread, so we're recommending New York -5.5 as the best bet for Game 5. ESPN BET has the best odds (-108) among our best sports betting apps for this play, with a $10 winning wager profiting $9.26.

✅ Best bet: Knicks -5.5 (-108 via ESPN BET)

📈 Pistons vs. Knicks odds

Live updated odds from our best sports betting sites.

🪧 Game 5 opening odds

Opening odds via BetMGM.

  • Spread: Pistons +5.5 (-115) | Knicks -5.5 (-105)
  • Moneyline: Pistons +180 | Knicks -220
  • Over/Under: Over 213.5 (-110) | Under 213.5 (-110)

🚑 Pistons vs. Knicks injury report

Follow the official NBA injury report for more injury news.

📡 How to watch Pistons vs. Knicks live (Game 5)

📅 Tuesday, April 29
🕗 7:30 p.m. ET
📍 Madison Square Garden (New York)
📺 TNT | 🛜 Max

🔮Today's NBA expert picks

💵 Best NBA betting sites

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Written By:
Gabe Henderson
Gabe Henderson is a sports betting writer from Houston, Texas. He graduated from Louisiana State University in 2022 with a bachelor's degree in Mass Communication. Gabe developed an interest in sports betting while in college due to its legalization in Louisiana. He turned his passion into a career shortly after, joining The Advocate/NOLA.com as a Sports Betting Content Coordinator, where he spent two years. Gabe wore many hats before graduating as he led FanSided's coverage of Chelsea FC as a Site Expert with "The Pride of London." He was also the Editor-in-Chief of the LSU Gumbo Yearbook for two years. Gabe became a part of the SportsbookReview.com team in late 2024. He brings with him an extensive knowledge of many sports, including — but not limited to — NFL, NCAA, MLB, NBA, soccer, and UFC.