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Phillies vs. Cubs Sunday Night Baseball Prediction, Odds & Expert Picks Today

Mike Spector

Last Updated: April 27, 2025 11:35 AM EDT • 3 min 8 sec read.

Phillies vs. Cubs Sunday Night Baseball Prediction & Picks: Best MLB Odds for April 27
Pictured: Philadelphia Phillies first baseman Bryce Harper (3) hits a two-run double against the Chicago Cubs. Photo by Kamil Krzaczynski via Imagn Images.

The Philadelphia Phillies (14-13) ended a five-game losing streak with Saturday's win over the Chicago Cubs (17-11), setting up a rubber match of the three-game series. Our Phillies vs. Cubs Sunday Night Baseball prediction backs the underdog visitors in an inevitable bounceback spot for Aaron Nola.

First pitch from Wrigley Field in Chicago is scheduled for 7 p.m. ET (ESPN).

We are looking to continue the momentum from yesterday’s 2-0 day, where we predicted a Phillies win and no runs in the first inning. Read on for our MLB picks for tonight's primetime game out of the National League.

💰 Best Phillies vs. Cubs predictions: Sunday Night Baseball

Here are my best Phillies vs. Cubs Sunday Night Baseball predictions for today's MLB matchup with my pick confidence based on a 1-to-5-star scale. Be sure to check out our guide on how to bet on the MLB.

🔢 Phillies vs. Cubs odds & betting lines

Here are the latest Visitor vs. Host odds and betting lines from our best live betting sites.

📊 Who will win today's Sunday Night Baseball matchup?

As of Sunday morning, the Cubs are favored to beat the Phillies in today's MLB matchup at 7 p.m. ET from Wrigley Field in Chicago. The Phillies have yet to win a series on the road this season, but I am still backing them to win this series finale as -105 moneyline underdogs.

🎯 Phillies vs. Cubs score prediction: Phillies 5, Cubs 3

The Phillies are 0-5 in Aaron Nola’s five starts, with the righty taking the loss in each. However, Philadelphia’s offense has scored one or fewer runs in three of those starts, and has not topped four runs anytime he has taken the rubber.

Nola’s lack of run support overshadows the fact that he still has solid metrics in ground ball rate (73rd percentile) and chase rate (81st percentile), and his ground ball rate is on pace to be his best since 2020 when he finished seventh in the Cy Young Award voting.

Cold weather and winds blowing in hard from left field the last two days have limited the home run potential of both teams. I expect that to have a bigger impact on the Cubs' offense tonight, as they entered Saturday leading the majors in slugging and on-base percentage.

I predict Philadelphia will beat Chicago by a final score of Phillies 5, Cubs 3.

Best bet: Phillies ML (-105 via BetMGM)

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1️⃣ Sunday Night Baseball first-inning prediction: NRFI

Nola’s 11.3 K/9 rate on the road trumps his 7.9 K/9 rate at home so far this season. While he has pitched to a 9.00 first-inning ERA this season (his worst of any of the first five innings), I expect him to match zeros early with Jameson Taillon, who is on pace for his second-lowest hard-hit rate allowed of the last six seasons.

A no run first inning is the best bet in this matchup.

🚑 Sunday Night Baseball injuries

Here are the latest injuries for tonight's Phillies vs. Cubs matchup, which will update in real time.

📺 How to watch Sunday Night Baseball

⚔️ Matchup: Phillies vs. Cubs
📅 Date: April 27
🕗 Time: 7 p.m. ET
📍 Location: Wrigley Field (Chicago)
📺 TV: ESPN
💻 Streaming: ESPN+

❓ Sunday Night Baseball FAQs

Who is favored to win Phillies vs. Cubs?

The Cubs are trading as -115 moneyline favorites at our best sports betting apps, which gives them a 53.49% implied probability. 

What are the odds for Phillies vs. Cubs?

The Phillies are as high as +165 to lay the -1.5 runs with the runline, while Chicago’s +1.5 odds are at -185. BetMGM is the only one of our best sportsbooks with a total of 7.5 runs (-120/+100), while the rest are in unison with an O/U of 8 runs.

What time is Phillies vs. Cubs tonight?

First pitch from Wrigley Field is scheduled for 7 p.m. ET.

How to watch Phillies vs. Cubs

The Phillies vs. Cubs Sunday Night Baseball matchup airs on ESPN.

🏆 MLB betting odds pages

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🧢 Best MLB betting sites

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Written By:
Mike Spector
Mike started in the sports writing industry in July 2019, and gained a lot of followers in his first year after finishing with the No. 2 overall record in an annual NFL betting competition, which made picks against the spread, and from an Over/Under and moneyline perspective. Mike is an avid fan of the NFL, MLB, tennis, and all college sports. In his opinion, March Madness is the best sporting event there is, and he's especially euphoric starting with conference tournament time in college basketball. Mike's a big advocate of "fading the public" and making plays that are contrarian, constantly citing that "there are reasons why they have those big shiny buildings in Las Vegas." When making wagers, Mike always scours the best odds at all of the major sports betting sites, where he mostly sifts through DraftKings, FanDuel, BetMGM, and bet365. He's tried several others and is of the firm belief that bettors should not just stick to one sportsbook, as there is always likely better value to be had with the same wager. In addition, while Mike received his undergraduate degree from Villanova University, he has no issue betting against the Wildcats when it comes to college basketball wagering, and suggests other bettors should always put their “head” before their “hearts.”